CONSIDERATIONS TO KNOW ABOUT ERASTIN MECHANISM OF ACTION

Erastin is a ferroptosis activator by acting on mitochondrial VDAC, exhibiting selectivity for tumor cells bearing oncogenic RAS. Answers are unstable and should be new-prepared.In conclusion, erastin can avoid extracellular cystine from getting into cells by inhibiting procedure XC−, which subsequently cuts down the intracellular GSH degree.TCI